IronSulferCluV1, Main, Exploration, bibRecord, 000211

Redox-dependent gating of VDAC by mitoNEET.

Identifieur interne : 000211 ( Main/Exploration ); précédent : 000210; suivant : 000212

Redox-dependent gating of VDAC by mitoNEET.

Auteurs : Colin H. Lipper [États-Unis] ; Jason T. Stofleth [États-Unis] ; Fang Bai [États-Unis] ; Yang-Sung Sohn [États-Unis] ; Susmita Roy [États-Unis] ; Ron Mittler [États-Unis] ; Rachel Nechushtai [Israël] ; José N. Onuchic [États-Unis] ; Patricia A. Jennings [États-Unis]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2019.

RBID : pubmed:31527235

Descripteurs français

English descriptors

KwdEn :
- 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid (chemistry), Animals (MeSH), Apoptosis (MeSH), Binding Sites (MeSH), Dimyristoylphosphatidylcholine (chemistry), Ferroptosis (MeSH), Homeostasis (MeSH), Humans (MeSH), Iron (chemistry), Iron (metabolism), Iron-Sulfur Proteins (metabolism), Kinetics (MeSH), Mitochondria (metabolism), Mitochondria, Liver (metabolism), Mitochondrial Membranes (metabolism), Mitochondrial Proteins (metabolism), Oxidation-Reduction (MeSH), Oxygen (chemistry), Protein Conformation (MeSH), Protein Interaction Mapping (MeSH), Protein Multimerization (MeSH), Protein Structure, Secondary (MeSH), Recombinant Proteins (chemistry), Sheep (MeSH), Voltage-Dependent Anion Channel 1 (metabolism).
MESH :
- chemical , chemistry : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid, Dimyristoylphosphatidylcholine, Iron, Oxygen, Recombinant Proteins.
- chemical , metabolism : Iron, Iron-Sulfur Proteins, Mitochondrial Proteins, Voltage-Dependent Anion Channel 1.
- metabolism : Mitochondria, Mitochondria, Liver, Mitochondrial Membranes.
- Animals, Apoptosis, Binding Sites, Ferroptosis, Homeostasis, Humans, Kinetics, Oxidation-Reduction, Protein Conformation, Protein Interaction Mapping, Protein Multimerization, Protein Structure, Secondary, Sheep.

Abstract

MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's diseases. In healthy cells, mitoNEET receives its clusters from the mitochondrion and transfers them to acceptor proteins in a process that could be altered by drugs or during illness. Here, we report that mitoNEET regulates the outer-mitochondrial membrane (OMM) protein voltage-dependent anion channel 1 (VDAC1). VDAC1 is a crucial player in the cross talk between the mitochondria and the cytosol. VDAC proteins function to regulate metabolites, ions, ROS, and fatty acid transport, as well as function as a "governator" sentry for the transport of metabolites and ions between the cytosol and the mitochondria. We find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonate (DIDS) prevents both mitoNEET binding in vitro and mitoNEET-dependent mitochondrial iron accumulation in situ. We find that the DIDS inhibitor does not alter the redox state of MitoNEET. Taken together, our data indicate that mitoNEET regulates VDAC in a redox-dependent manner in cells, closing the pore and likely disrupting VDAC's flow of metabolites.

DOI: 10.1073/pnas.1908271116
PubMed: 31527235
PubMed Central: PMC6778226

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000226
to stream Main, to step Curation: 000226

Le document en format XML

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<term>Animals (MeSH)</term>
<term>Apoptosis (MeSH)</term>
<term>Binding Sites (MeSH)</term>
<term>Dimyristoylphosphatidylcholine (chemistry)</term>
<term>Ferroptosis (MeSH)</term>
<term>Homeostasis (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Iron (chemistry)</term>
<term>Iron (metabolism)</term>
<term>Iron-Sulfur Proteins (metabolism)</term>
<term>Kinetics (MeSH)</term>
<term>Mitochondria (metabolism)</term>
<term>Mitochondria, Liver (metabolism)</term>
<term>Mitochondrial Membranes (metabolism)</term>
<term>Mitochondrial Proteins (metabolism)</term>
<term>Oxidation-Reduction (MeSH)</term>
<term>Oxygen (chemistry)</term>
<term>Protein Conformation (MeSH)</term>
<term>Protein Interaction Mapping (MeSH)</term>
<term>Protein Multimerization (MeSH)</term>
<term>Protein Structure, Secondary (MeSH)</term>
<term>Recombinant Proteins (chemistry)</term>
<term>Sheep (MeSH)</term>
<term>Voltage-Dependent Anion Channel 1 (metabolism)</term>
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<term>Animaux (MeSH)</term>
<term>Apoptose (MeSH)</term>
<term>Canal anionique-1 voltage-dépendant (métabolisme)</term>
<term>Cartographie d'interactions entre protéines (MeSH)</term>
<term>Cinétique (MeSH)</term>
<term>Conformation des protéines (MeSH)</term>
<term>Dimyristoylphosphatidylcholine (composition chimique)</term>
<term>Fer (composition chimique)</term>
<term>Fer (métabolisme)</term>
<term>Ferrosulfoprotéines (métabolisme)</term>
<term>Homéostasie (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Membranes mitochondriales (métabolisme)</term>
<term>Mitochondries (métabolisme)</term>
<term>Mitochondries du foie (métabolisme)</term>
<term>Multimérisation de protéines (MeSH)</term>
<term>Ovis (MeSH)</term>
<term>Oxydoréduction (MeSH)</term>
<term>Oxygène (composition chimique)</term>
<term>Protéines mitochondriales (métabolisme)</term>
<term>Protéines recombinantes (composition chimique)</term>
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<term>Mitochondrial Proteins</term>
<term>Voltage-Dependent Anion Channel 1</term>
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<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Acide 4,4'-diisothiocyano-stilbène-2,2'-disulfonique</term>
<term>Dimyristoylphosphatidylcholine</term>
<term>Fer</term>
<term>Oxygène</term>
<term>Protéines recombinantes</term>
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<term>Ferrosulfoprotéines</term>
<term>Membranes mitochondriales</term>
<term>Mitochondries</term>
<term>Mitochondries du foie</term>
<term>Protéines mitochondriales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Binding Sites</term>
<term>Ferroptosis</term>
<term>Homeostasis</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Oxidation-Reduction</term>
<term>Protein Conformation</term>
<term>Protein Interaction Mapping</term>
<term>Protein Multimerization</term>
<term>Protein Structure, Secondary</term>
<term>Sheep</term>
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<term>Cartographie d'interactions entre protéines</term>
<term>Cinétique</term>
<term>Conformation des protéines</term>
<term>Homéostasie</term>
<term>Humains</term>
<term>Multimérisation de protéines</term>
<term>Ovis</term>
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<front><div type="abstract" xml:lang="en">MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's diseases. In healthy cells, mitoNEET receives its clusters from the mitochondrion and transfers them to acceptor proteins in a process that could be altered by drugs or during illness. Here, we report that mitoNEET regulates the outer-mitochondrial membrane (OMM) protein voltage-dependent anion channel 1 (VDAC1). VDAC1 is a crucial player in the cross talk between the mitochondria and the cytosol. VDAC proteins function to regulate metabolites, ions, ROS, and fatty acid transport, as well as function as a "governator" sentry for the transport of metabolites and ions between the cytosol and the mitochondria. We find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonate (DIDS) prevents both mitoNEET binding in vitro and mitoNEET-dependent mitochondrial iron accumulation in situ. We find that the DIDS inhibitor does not alter the redox state of MitoNEET. Taken together, our data indicate that mitoNEET regulates VDAC in a redox-dependent manner in cells, closing the pore and likely disrupting VDAC's flow of metabolites.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31527235</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>116</Volume>
<Issue>40</Issue>
<PubDate><Year>2019</Year>
<Month>10</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation>
</Journal>
<ArticleTitle>Redox-dependent gating of VDAC by mitoNEET.</ArticleTitle>
<Pagination><MedlinePgn>19924-19929</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1908271116</ELocationID>
<Abstract><AbstractText>MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's diseases. In healthy cells, mitoNEET receives its clusters from the mitochondrion and transfers them to acceptor proteins in a process that could be altered by drugs or during illness. Here, we report that mitoNEET regulates the outer-mitochondrial membrane (OMM) protein voltage-dependent anion channel 1 (VDAC1). VDAC1 is a crucial player in the cross talk between the mitochondria and the cytosol. VDAC proteins function to regulate metabolites, ions, ROS, and fatty acid transport, as well as function as a "governator" sentry for the transport of metabolites and ions between the cytosol and the mitochondria. We find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonate (DIDS) prevents both mitoNEET binding in vitro and mitoNEET-dependent mitochondrial iron accumulation in situ. We find that the DIDS inhibitor does not alter the redox state of MitoNEET. Taken together, our data indicate that mitoNEET regulates VDAC in a redox-dependent manner in cells, closing the pore and likely disrupting VDAC's flow of metabolites.</AbstractText>
<CopyrightInformation>Copyright © 2019 the Author(s). Published by PNAS.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lipper</LastName>
<ForeName>Colin H</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0375.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stofleth</LastName>
<ForeName>Jason T</ForeName>
<Initials>JT</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0375.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bai</LastName>
<ForeName>Fang</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Physics and Astronomy, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Chemistry, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biosciences, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sohn</LastName>
<ForeName>Yang-Sung</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roy</LastName>
<ForeName>Susmita</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Physics and Astronomy, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Chemistry, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biosciences, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mittler</LastName>
<ForeName>Ron</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65201.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65201.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nechushtai</LastName>
<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Onuchic</LastName>
<ForeName>José N</ForeName>
<Initials>JN</Initials>
<AffiliationInfo><Affiliation>Center for Theoretical Biological Physics, Rice University, Houston, TX 77005; jonuchic@rice.edu pajennings@ucsd.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Physics and Astronomy, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Chemistry, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biosciences, Rice University, Houston, TX 77005.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jennings</LastName>
<ForeName>Patricia A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0375; jonuchic@rice.edu pajennings@ucsd.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>09</Month>
<Day>16</Day>
</ArticleDate>
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<MedlineTA>Proc Natl Acad Sci U S A</MedlineTA>
<NlmUniqueID>7505876</NlmUniqueID>
<ISSNLinking>0027-8424</ISSNLinking>
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<NameOfSubstance UI="C525595">CISD1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007506">Iron-Sulfur Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D024101">Mitochondrial Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>E1UOL152H7</RegistryNumber>
<NameOfSubstance UI="D007501">Iron</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.6.-</RegistryNumber>
<NameOfSubstance UI="D050995">Voltage-Dependent Anion Channel 1</NameOfSubstance>
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<NameOfSubstance UI="D017878">4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid</NameOfSubstance>
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<NameOfSubstance UI="D004134">Dimyristoylphosphatidylcholine</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D017878" MajorTopicYN="N">4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004134" MajorTopicYN="N">Dimyristoylphosphatidylcholine</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D007501" MajorTopicYN="N">Iron</DescriptorName>
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<MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008930" MajorTopicYN="N">Mitochondria, Liver</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051336" MajorTopicYN="N">Mitochondrial Membranes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024101" MajorTopicYN="N">Mitochondrial Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010084" MajorTopicYN="Y">Oxidation-Reduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025941" MajorTopicYN="N">Protein Interaction Mapping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017433" MajorTopicYN="N">Protein Structure, Secondary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012756" MajorTopicYN="N">Sheep</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050995" MajorTopicYN="N">Voltage-Dependent Anion Channel 1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">CISD1</Keyword>
<Keyword MajorTopicYN="Y">VDAC1</Keyword>
<Keyword MajorTopicYN="Y">direct coupling</Keyword>
<Keyword MajorTopicYN="Y">ferroptosis</Keyword>
<Keyword MajorTopicYN="Y">mitoNEET</Keyword>
</KeywordList>
<CoiStatement>The authors declare no conflict of interest.</CoiStatement>
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</ArticleIdList>
<ReferenceList><Reference><Citation>PLoS One. 2016 May 31;11(5):e0156054</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27243905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):516-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21636891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):948-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23271805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Methods. 2017 Jan;14(1):49-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27869813</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E252-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14570702</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Proteomics. 2004 Dec;3(12):1211-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15501831</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5177-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24706857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2015 Jun;1853(6):1294-315</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25448035</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2016 Oct 21;291(43):22482-22495</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27573244</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1996 May 20;386(2-3):205-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8647283</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutrients. 2013 May 10;5(5):1544-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23666091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14342-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17766440</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8051-E8058</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27911825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2018 Sep 25;57(38):5616-5628</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30204426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2015 Dec 25;290(52):30670-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26542804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Platelets. 2018 Nov;29(7):723-728</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29090588</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Cancer Res. 2018;138:41-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29551129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2012 Oct;18(10):1539-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22961109</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2015 Dec 02;10(12):e0144067</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26630011</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Chem. 2007;14(22):2344-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17896983</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Methods. 2015 Jan;12(1):7-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25549265</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2007 Jan 16;46(2):514-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17209561</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2011 Oct 28;147(3):690-703</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22036573</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2015 Apr;81:119-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25645953</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2015 Oct 08;10(10):e0139699</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26448442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Res. 2018 May;131:87-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29551631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1979 Jun 14;279(5714):643-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">450112</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2014 Oct 10;289(41):28070-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25012650</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2006 Feb;1762(2):181-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16307870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1268-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20138821</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2015 Dec 15;472(3):329-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26443864</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Chem Soc. 2010 Sep 29;132(38):13120-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20812736</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes. 2003 Jan;52(1):1-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12502486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2015 Jul 1;43(W1):W30-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25943547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2012 Jun;1818(6):1526-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22100746</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biomed Sci. 2001 Jan-Feb;8(1):59-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11173977</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2017 Jun 16;292(24):10061-10067</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28461337</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2018 Mar 19;8(1):4840</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29556009</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2009 Nov 3;48(43):10193-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19791753</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2004 Jan 15;377(Pt 2):347-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14561215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Hum Genet. 2007 Oct;81(4):673-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17846994</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Apr 26;288(17):11920-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23471966</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Alcohol. 2004 Aug;34(1):9-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15670660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Biochem Biophys. 2010 Mar 15;495(2):174-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20097153</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biomed Sci. 2008 Jun;4(2):89-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23675073</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14676-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23959881</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Alzheimers Dis. 2013;37(4):679-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23948905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10890-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27621439</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1997 Jul 25;272(30):18966-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9228078</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5318-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17376863</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2009 Jan 1;417(1):1-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19061483</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Sep 18;284(38):26137-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19592498</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2013 Jul 10;425(13):2382-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23499887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Sep 17;525(7569):339-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26344197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2016 Sep 16;478(2):838-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27510639</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2011 Jul 1;410(1):131-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21600902</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3698-703</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25762074</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Apr 6;287(15):11649-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22351774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Comput Biol. 2013;9(9):e1003188</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24039559</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2017 Feb 16;7:42571</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28205535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2012 Jun;1818(6):1466-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22020053</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2005 Dec 20;1710(2-3):96-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16293222</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Chem Biol. 2014 Apr;19:50-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24463764</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2016 Apr 1;291(14):7583-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26887944</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2017 Jul 7;429(14):2178-2191</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28576472</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2008 Jan 25;365(4):856-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18047834</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Biochem Biophys. 2009 Jan 15;481(2):226-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19014900</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2009 May 15;23(10):1183-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19451219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Membr Biol. 1976 Dec 28;30(2):99-120</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1011248</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Physiol. 2003 Oct 15;552(Pt 2):335-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14561818</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cold Spring Harb Protoc. 2014 Jan 01;2014(1):94-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24371315</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2019 Jan 21;2019:9817576</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30805086</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Aspects Med. 2010 Jun;31(3):227-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20346371</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Aug 17;282(33):23745-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17584744</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 1994 Jun 29;1197(2):167-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8031826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13047-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21788481</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2012 May;24(5):2139-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22562611</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Indian J Clin Biochem. 2015 Jan;30(1):11-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25646037</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2014 Feb 14;289(7):4307-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24403080</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 Jan;1832(1):67-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22995655</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2014;10(12):2279-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25470454</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bioenerg Biomembr. 2008 Jun;40(3):163-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18654841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1990 Oct 5;215(3):403-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2231712</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Discov Today. 2014 Oct;19(10):1601-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24814435</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 May 22;8(5):e61202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23717386</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Nov 16;282(46):33242-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17905743</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Chem Hoppe Seyler. 1994 Aug;375(8):513-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7529026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14640-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17766439</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Redox-dependent gating of VDAC by mitoNEET.

Redox-dependent gating of VDAC by mitoNEET.

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